Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension
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چکیده
منابع مشابه
Mediation of pinocytosis in cultured arterial smooth muscle and endothelial cells by platelet-derived growth factor
Pinocytosis was measured in monkey aortic smooth muscle cells (SMC), bovine aortic endothelial cells, and Swiss 3T3 cells in culture as cellular uptake of [U-(14)C]sucrose and horseradish peroxidase (HRP) from the tissue culture medium. Monkey arterial SMC and Swiss 3T3 cells were maintained in a quiescent state of growth at low cells density in medium containing 5 percent monkey plasma-derived...
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RATIONALE Platelet-derived growth factor (PDGF) promotes the proliferation and migration of pulmonary artery smooth muscle cells (PASMCs), and may play a role in the progression of pulmonary arterial hypertension (PAH), a condition characterized by proliferation of PASMCs resulting in the obstruction of small pulmonary arteries. OBJECTIVES To analyze the expression and pathogenic role of PDGF...
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ژورنال
عنوان ژورنال: Pulmonary Circulation
سال: 2020
ISSN: 2045-8940,2045-8940
DOI: 10.1177/2045894020948470